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50
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Here, notice that while the mean of the average number on the dice remains the same at 3.5, the standard deviation decreases (as the number of dice increases) as follows:
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equals
7
Correspondingly, the probability that the average number on the dice is 4 or beyond also decreases from 50% (in the case of 1 die) to ~2% (in the case of 50 dice) — as can be seen in the shaded area in the graph.
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In other words, whereas getting an average of 4 or beyond is pretty normal when throwing one die, the same becomes an extreme rarity when 50 dice are involved (and thus is taken as a statistically significant evidence that the die is biased). For more on statistical significance, see https://mathvault.ca/statistical-significance
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